Iron's Role in Rickettsial Infection of Eukaryotic Hosts. - Joseph Dinoto
Rickettsia are obligate intracellular pathogens that are responsible for Rocky Mountian Spotted Fever and Epidemic Typhus. A recent genomic analysis suggests that rickettsia are among the group of organisms that require iron for life. This study will focus on the role that iron plays in the ability of Rickettsia to infect eukaryotic host cells. The goal of the study is first to determine whether iron has a role in infection, and secondarily to compare the regulation of putative iron-related genes throughout the infection process.